Article
High-throughput allele-specific expression across 250 environmental conditions.
Genome research - 1 Dec 2016
Moyerbrailean Gregory A, Richards Allison L, Kurtz Daniel, Kalita Cynthia A, Davis Gordon O, Harvey Chris T, Alazizi Adnan, Watza Donovan, Sorokin Yoram, Hauff Nancy, Zhou Xiang, Wen Xiaoquan, Pique-Regi Roger, Luca Francesca
Abstract excerpt
Gene-by-environment (GxE) interactions determine common disease risk factors and biomedically relevant complex traits. However, quantifying how the environment modulates genetic effects on human quantitative phenotypes presents unique challenges. Environmental covariates are complex and difficult to measure and control at the organismal level, as found in GWAS and epidemiological studies. An alternative approach...
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