Article

An integrated approach to identify environmental modulators of genetic risk factors for complex traits

2021-02-25

Abstract excerpt

Complex traits and diseases can be influenced by both genetics and environment. However, given the large number of environmental stimuli and power challenges for gene-by-environment testing, it remains a critical challenge to identify and prioritize specific disease-relevant environmental exposures. We propose a novel framework for leveraging signals from transcriptional responses to environmental perturbations to...

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Literature Corpus work: ad548e82-fa0c-5de0-8cb7-9bc30ab12487
DOI: 10.1101/2021.02.23.432608

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