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Article

An integrated approach to identify environmental modulators of genetic risk factors for complex traits.

American journal of human genetics - 7 Oct 2021

Balliu Brunilda, Carcamo-Orive Ivan, Gloudemans Michael J, Nachun Daniel C, Durrant Matthew G, Gazal Steven, Park Chong Y, Knowles David A, Wabitsch Martin, Quertermous Thomas, Knowles Joshua W, Montgomery Stephen B

Abstract excerpt

Complex traits and diseases can be influenced by both genetics and environment. However, given the large number of environmental stimuli and power challenges for gene-by-environment testing, it remains a critical challenge to identify and prioritize specific disease-relevant environmental exposures. We propose a framework for leveraging signals from transcriptional responses to environmental perturbations to...

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Identifiers

PMID: 34582792
DOI: 10.1016/j.ajhg.2021.08.014
PMCID: PMC8546041

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