Article

Diverse environmental perturbations reveal the evolution and context-dependency of genetic effects on gene expression levels

2021-11-04

Abstract excerpt

There is increasing appreciation that human complex traits are determined by poorly understood interactions between our genomes and daily environments. These “genotype x environment” (GxE) interactions remain difficult to map at the organismal level, but can be uncovered using molecular phenotypes. To do so at large-scale, we profiled transcriptomes across 12 cellular environments using 544 immortalized B cell lin...

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Literature Corpus work: 159eb177-82de-5ea1-b2b0-d2770b8b2d3b
DOI: 10.1101/2021.11.04.467311

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