Article
Determinants of mosaic chromosomal alteration fitness
2023-10-21
Abstract excerpt
Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger structural rearrangements called mosaic chromosomal alterations (mCAs). The factors that influence the variations in mCA fitness and ultimately result in different clonal expansi...
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Identifiers and source
- Literature Corpus work
- ea5adc91-2d6a-5677-b83d-7d13094e5a74
- DOI
- 10.1101/2023.10.20.23297280