Article
Determinants of mosaic chromosomal alteration fitness.
Nature communications - 7 May 2024
Pershad Yash, Mack Taralynn, Poisner Hannah, Jakubek Yasminka A, Stilp Adrienne M, Mitchell Braxton D, Lewis Joshua P, Boerwinkle Eric, Loos Ruth J F, Chami Nathalie, Wang Zhe, Barnes Kathleen, Pankratz Nathan, Fornage Myriam, Redline Susan, Psaty Bruce M, Bis Joshua C, Shojaie Ali, Silverman Edwin K, Cho Michael H, Yun Jeong H, DeMeo Dawn, Levy Daniel, Johnson Andrew D, Mathias Rasika A, Taub Margaret A, Arnett Donna, North Kari E, Raffield Laura M, Carson April P, Doyle Margaret F, Rich Stephen S, Rotter Jerome I, Guo Xiuqing, Cox Nancy J, Roden Dan M, Franceschini Nora, Desai Pinkal, Reiner Alex P, Auer Paul L, Scheet Paul A, Jaiswal Siddhartha, Weinstock Joshua S, Bick Alexander G
Abstract excerpt
Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger structural rearrangements called mosaic chromosomal alterations (mCAs). The factors that influence the variations in mCA fitness and ultimately result in different clonal...
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