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Article

Shared and distinct genetic etiologies for different types of clonal hematopoiesis.

Nature communications - 8 Sept 2023

Brown Derek W, Cato Liam D, Zhao Yajie, Nandakumar Satish K, Bao Erik L, Gardner Eugene J, Hubbard Aubrey K, DePaulis Alexander, Rehling Thomas, Song Lei, Yu Kai, Chanock Stephen J, Perry John R B, Sankaran Vijay G, Machiela Mitchell J

Abstract excerpt

Clonal hematopoiesis (CH)-age-related expansion of mutated hematopoietic clones-can differ in frequency and cellular fitness by CH type (e.g., mutations in driver genes (CHIP), gains/losses and copy-neutral loss of chromosomal segments (mCAs), and loss of sex chromosomes). Co-occurring CH raises questions as to their origin, selection, and impact. We integrate sequence and genotype array data in up to 482,378 UK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Modification Methylases

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Source

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Identifiers

PMID: 37684235
DOI: 10.1038/s41467-023-41315-5
PMCID: PMC10491829

Genes

DNMT3A
JAK2
TET2

Provenance

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