Article

Longitudinal characterization of mosaic chromosomal alterations identifies factors influencing clonal dynamics of leukocytes

2026-07-29

Abstract excerpt

Abstract Characterizing the variation in clonal trajectory of age-related mosaic chromosomal alterations (mCAs) in circulating leukocytes can identify etiologic factors influencing clonal expansion and hematologic malignancy risk. Here we scan whole blood-derived DNA of 56,324 participants from the Prostate, Lung, Colorectal, Ovarian Cancer Screening Study for mCAs and characterize 1746 longitudinal mCAs. Cross-se...

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Literature Corpus work: 8ea52ec2-ea7b-50d4-93fd-9f807bd38231
DOI: 10.1038/s41467-026-75996-5

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