Article

Shared and distinct genetic etiologies for different types of clonal hematopoiesis

2022-03-14

Abstract excerpt

Clonal hematopoiesis (CH) – age-related expansion of mutated hematopoietic clones – can differ in frequency and cellular fitness. Descriptive studies have identified a spectrum of events (coding mutations in driver genes (CHIP), gains/losses and copy-neutral loss of chromosomal segments (mCAs), and loss of sex chromosomes). Co-existence of different CH events raises key questions as to their origin, selection, and...

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Literature Corpus work: ef8af316-8232-5c46-86d8-b920ea7782c6
DOI: 10.1101/2022.03.14.483644

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