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Article

Germline risk of clonal haematopoiesis.

Nature reviews. Genetics - 1 Sept 2021

Silver Alexander J, Bick Alexander G, Savona Michael R

Abstract excerpt

Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with somatic mutations that is associated with an increased risk of haematological malignancies, cardiovascular disease and all-cause mortality. CH may be caused by point mutations in genes associated with myeloid neoplasms, chromosomal copy number changes and loss of heterozygosity events. How inherited and environmental factors shape...

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Identifiers

PMID: 33986496
DOI: 10.1038/s41576-021-00356-6
PMCID: PMC8117131

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