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Article

Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations.

Human genomics - 2 Dec 2025

Colin-Leitzinger Christelle, Tang Yi-Han, Teng Mingxiang, Gillis Nancy

Abstract excerpt

Somatic mosaicism (SM), the presence of somatic mutations, is classified as clonal hematopoiesis (CH) when it occurs in hematopoietic cells at an age-related rate. CH is associated with risk for hematologic malignancies and cardiovascular disease, but most studies are predominately based on individuals of European ancestry. Using peripheral blood whole exome sequencing data from 125,748 individuals of diverse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41331781
DOI: 10.1186/s40246-025-00847-1
PMCID: PMC12673770

Genes

CUX1
NF1
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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