Article

Peripheral blood somatic mosaicism and clonal hematopoiesis across ancestry backgrounds

2025-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Somatic mosaicism (SM), the presence of somatic mutations, is classified as clonal hematopoiesis (CH) when it occurs in hematopoietic cells at an age-related rate. CH is associated with risk for hematologic malignancies and cardiovascular disease, but most studies are predominately based on individuals of European ancestry. Using peripheral blood whole exome sequencing data from 125,748 individua...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f36d077-7b6f-50b9-85ca-f747e4063b11
DOI: 10.1101/2025.03.21.25324408

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Peripheral blood somatic mosaicism and clonal hematopoiesis across ancestry backgroundsDOI 10.1101/2025.03.21.25324408Read

Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations.Semantic proximity Read

Mutational Architecture of Clonal Hematopoiesis of Indeterminate Potential in 29,596 Chinese IndividualsSemantic proximity Read

Genomic and phenomic landscape of clonal hematopoiesis in over a million ancestrally diverse participantsSemantic proximity Read

Multi-ancestry analysis of 791K whole genomes reveals the genetic, geographic, and phenotypic correlates of somatic passenger mutations in bloodSemantic proximity Read

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets.Semantic proximity Read

Shared and distinct genetic etiologies for different types of clonal hematopoiesis.Semantic proximity Read

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic datasetsSemantic proximity Read

Shared and distinct genetic etiologies for different types of clonal hematopoiesisSemantic proximity Read

Exome sequencing of 628,388 individuals identifies common and rare variant associations with clonal hematopoiesis phenotypesSemantic proximity Read

Mosaic chromosomal alterations in blood across ancestries via whole-genome sequencingSemantic proximity Read

Patterns and drivers of 43,617 mosaic chromosomal alterations in bloodSemantic proximity Read

The Somatic Mosaicism across Human Tissues Network.Semantic proximity Read