Article
Monogenic and polygenic inheritance become instruments for clonal selection
2019-05-29
Abstract excerpt
Clonally expanded blood cells with somatic mutations (clonal hematopoiesis, CH) are commonly acquired with age and increase risk of later blood cancer. To identify genes and mutations that give selective advantage to mutant clones, we identified among 482,789 UK Biobank participants some 19,632 autosomal mosaic chromosomal alterations (mCAs), including deletions, duplications, and copy number-neutral loss of heter...
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Identifiers and source
- Literature Corpus work
- d49dff07-649a-557f-b576-43f869144462
- DOI
- 10.1101/653691