Article

ALK5/Smad signaling mediates rapamycin therapeutic response and TET2-dependent chromatin remodeling in vascular smooth muscle cell differentiation

2024-04-29

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Vascular smooth muscle cell (VSMC) phenotypic switching contributes to vascular repair and remodeling but also to pathologies including intimal hyperplasia. The mTORC1 inhibitor rapamycin is an effective drug-eluting stent agent that promotes VSMC differentiation. TGFβ also promotes VSMC differentiation through SMAD transcription factors. We investigated unexpec...

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Literature Corpus work: ea52ceba-2435-5918-bd25-e04ec984e07a
DOI: 10.21203/rs.3.rs-4283747/v1

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