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Article

The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation.

American journal of physiology. Cell physiology - 1 Mar 2004

Martin Kathleen A, Rzucidlo Eva M, Merenick Bethany L, Fingar Diane C, Brown David J, Wagner Robert J, Powell Richard J

Abstract excerpt

Vascular smooth muscle cells (VSMC) in mature, normal blood vessels exhibit a differentiated, quiescent, contractile morphology, but injury induces a phenotypic modulation toward a proliferative, dedifferentiated, migratory phenotype with upregulated extracellular matrix protein synthesis (synthetic phenotype), which contributes to intimal hyperplasia. The mTOR (the mammalian target of rapamycin) pathway...

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PMID: 14592809
DOI: 10.1152/ajpcell.00201.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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