Article

Transforming growth factor-beta signaling via ALK1 and ALK5 regulates distinct functional pathways in vein graft intimal hyperplasia

2019-11-29

Abstract excerpt

<h4>Rationale</h4> Transforming growth factor-beta (TGFβ) is tightly regulated at multiple levels, with regulation at the receptor level now recognized as a key determinant of the cellular response to this pleiotropic cytokine. TGFβ promotes saphenous vein graft neointima formation after coronary artery bypass graft (CABG) surgery, inducing smooth muscle cell (SMC) hyperplasia and fibrosis by signaling via activi...

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Literature Corpus work: 66ce4cb9-c606-5689-b993-73b7bfc3d459
DOI: 10.1101/860320

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