Article

Network-based prioritisation and validation of novel regulators of vascular smooth muscle cell proliferation in disease

2023-08-26

Abstract excerpt

Aberrant vascular smooth muscle cell (VSMC) homeostasis and proliferation are hallmarks of vascular diseases causing heart attack and stroke. To elucidate molecular determinants governing VSMC proliferation, we reconstructed gene regulatory networks from single cell transcriptomics and epigenetic profiling. We find progressive activation of enhancers at disease-relevant loci in VSMCs that don’t respond to injury a...

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Literature Corpus work: 4dd28afe-6296-5bd5-9758-879a51da0650
DOI: 10.1101/2023.08.25.554834

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