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Sotatercept Reverses SIN3a Deficiency-Driven PAH by Reprogramming BMPR2/TGF-β-HIF-1α Signaling Pathways

2026-02-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Pulmonary arterial hypertension is a progressive and fatal cardiopulmonary disease marked by excessive proliferation of pulmonary artery smooth muscle cells (PASMCs), pathological vascular remodeling, and ultimately right heart failure. Dysregulated BMPR2 signaling is a central molecular hallmark of PAH and is often associated with epigenetic suppression of BMPR2 expression....

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Literature Corpus work: 94708a64-5415-5f94-968d-65cd3ac29f78
DOI: 10.64898/2026.02.03.703590

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