Article

Genomic, transcriptomic and proteomic depiction of iPSC-derived smooth muscle cells as emerging cellular models for arterial diseases

2022-05-01

Abstract excerpt

<h4>Background</h4> Vascular smooth muscle cells (VSMCs) plasticity is a central mechanism in cardiovascular health and disease. We aimed at providing deep cellular phenotyping, epigenomic and proteomic depiction of SMCs derived from induced pluripotent stem cells (iPSCs) and evaluating their potential as cellular models in the context of complex genetic arterial diseases. <h4>Methods</h4> We differentiated 3 hu...

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Literature Corpus work: 15b6a853-6cb1-50f7-9a8e-3a49fe5bf3b6
DOI: 10.1101/2022.05.01.490058

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