Article

Extrafollicular responses are sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus

2022-03-04

Abstract excerpt

Many autoimmune diseases are characterized by germinal center (GC) derived affinity-matured, class-switched autoantibodies. Strategies to block GC formation and progression are currently being explored clinically, however, extrafollicular responses may also contribute to early events in autoimmunity. To investigate the relative contribution of these two pathways in autoimmune disease development, we leveraged a tr...

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Literature Corpus work: b05e0c21-e064-5e24-a725-a06cb45a9030
DOI: 10.1101/2022.03.04.482991

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