Article

Autoantibody origins in lupus and in relapse post CAR-T therapy

2025-10-20

Abstract excerpt

<h4>Summary</h4> Anti-CD19 chimeric antigen receptor (CAR)-T therapy induces profound remissions in lupus by depleting B cells, challenging the longstanding view that treatment-resistant disease is sustained by long-lived plasma cells. Additionally, emerging relapses highlight the need to understand how pathogenic autoantibodies arise. Using molecular antibody tagging in mice with human monogenic lupus variants,...

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Literature Corpus work: 0f2fdd8f-f2c5-56fc-b29d-618e1e330018
DOI: 10.1101/2025.10.20.683393

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