Article

CNS antigen-specific control of early B-lineage development in the meninges

2021-06-03

Abstract excerpt

The random V(D)J recombination of immunoglobulins (Ig) loci often creates autoreactive B cell progenitors expressing self-recognized B-cell receptors (BCRs) 1 , which are eliminated or inactivated through an autoantigen-dependent central tolerance checkpoint to prevent autoimmune reactions 2,3 , a process thought to be restricted to the bone marrow (BM) in the adult mammals 4 . Here we report that early develop...

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Literature Corpus work: 89cac045-bc27-5086-9c0b-d3761a34f036
DOI: 10.1101/2021.06.03.446985

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