Article

PPP2CA Drives Chondrocyte Metabolic Disorders and Underpins Osteoarthritis Pathogenesis through Targeting AMPK Dephosphorylation

2026-04-16

Abstract excerpt

<title>Abstract</title> <p> Osteoarthritis (OA) is a debilitating degenerative joint disease with limited therapeutic options. Emerging evidence implicates that metabolic disorder is the major risk factor in OA pathogenesis, with dysfunction in AMP-activated protein kinase (AMPK) signaling. AMPK is a central metabolic sensor and is activated by phosphorylation and inactivated by dephosphorylation. Dysruption of...

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Literature Corpus work: ea018552-5735-5be0-ac85-1459373d48f6
DOI: 10.21203/rs.3.rs-9176742/v1

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