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Article

Ageing and the pathogenesis of osteoarthritis.

Nature reviews. Rheumatology - 1 Jul 2016

Loeser Richard F, Collins John A, Diekman Brian O

Abstract excerpt

Ageing-associated changes that affect articular tissues promote the development of osteoarthritis (OA). Although ageing and OA are closely linked, they are independent processes. Several potential mechanisms by which ageing contributes to OA have been elucidated. This Review focuses on the contributions of the following factors: age-related inflammation (also referred to as 'inflammaging'); cellular senescence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27192932
DOI: 10.1038/nrrheum.2016.65
PMCID: PMC4938009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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