Article

AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcification

2025-02-01

Abstract excerpt

<h4>ABSTRACT</h4> Tendinopathy is a debilitating tendon disorder affecting millions of people, characterized by pain, swelling, and diminished biomechanical properties. While the precise mechanisms underlying tendon homeostasis remain unclear, metabolic regulation plays a critical role. In this study, we combine transcriptomic analysis of human tendinopathic samples with a conditional mouse model in which Prkaa1...

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Literature Corpus work: 297ab541-1b5c-53c1-bc64-0b10e60a5f8a
DOI: 10.1101/2025.01.31.635920

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