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Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling

24 Feb 2024

Abstract excerpt

Osteoarthritis (OA) is a debilitating chronic joint disease affecting large populations of patients, especially the elderly. The pathological mechanisms of OA are currently unknown. Multiple risk factors are involved in OA development. Among these risk factors, alterations of mechanical loading in the joint leading to changes in biological signaling pathways have been known as a key event in OA development. The...

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PMID: 39552787
DOI: 10.1016/j.gendis.2024.101247

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