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Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation

2024-07-24

Abstract excerpt

<h4>Objectives</h4> Chondrocyte metabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein post-translational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK) and its regulator Sirt5 in OA development. <h4>Methods</h4> Human and mouse cartilage tissues wer...

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Identifiers and source

Literature Corpus work
75091a3f-e89b-5f29-8cbf-241ad115295a
DOI
10.1101/2024.07.23.604872
Open publication

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Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylationDOI 10.1101/2024.07.23.604872
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