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Article

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease.

Journal of internal medicine - 1 Dec 2014

Grahame Hardie D

Abstract excerpt

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that regulates cellular and whole-body energy balance. A recently reported crystal structure has illuminated the complex regulatory mechanisms by which AMP and ADP cause activation of AMPK, involving phosphorylation by the upstream kinase LKB1. Once activated by falling cellular energy status, AMPK activates catabolic pathways that...

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Identifiers

PMID: 24824502
DOI: 10.1111/joim.12268
PMCID: PMC5705060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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