Article

PPAR-γ/PCK1 metabolic pathway modulate synovitis and fibrosis in KOA rats

2026-08-11

Abstract excerpt

<h4>Background</h4> Knee osteoarthritis (KOA) is a prevalent degenerative joint disease in which synovial inflammation and fibrosis are closely linked to pain, stiffness, and functional limitation. Growing evidence suggests that metabolic dysregulation, particularly in lipid metabolism, is involved in KOA pathogenesis, but the underlying mechanisms remain incompletely defined. <h4>Methods</h4> Sprague Dawley rat...

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Literature Corpus work: 79822a0f-288d-59fe-8c7e-00410817a011
DOI: 10.64898/2026.08.05.742949

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