Article

Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner

2024-06-01

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies have identified a protective mutation in the phospholipase C gamma 2 ( PLCG2 ) gene which confers protection against Alzheimer’s disease (AD)-associated cognitive decline. Therefore, PLCG2, which is primarily expressed in immune cells, has become a target of interest for potential therapeutic intervention. The protective allele, known as P522R , has been shown t...

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Literature Corpus work: 1f280479-a9e8-5bdf-8cae-c498f6ea8aed
DOI: 10.1101/2024.05.28.596275

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