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Global H3.3 dynamic deposition defines its bimodal role in cell fate transition

12 Apr 2018

Abstract excerpt

H3.3 is a histone variant, which is deposited on genebodies and regulatory elements, by Hira, marking active transcription. Moreover, H3.3 is deposited on heterochromatin by Atrx/Daxx complex. The exact role of H3.3 in cell fate transition remains elusive. Here, we investigate the dynamic changes in the deposition of the histone variant H3.3 during cellular reprogramming. H3.3 maintains the identities of the...

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PMID: 29670118
DOI: 10.1038/s41467-018-03904-7

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