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Article

Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains.

Nature communications - 3 Mar 2021

Gopi Lijin K, Kidder Benjamin L

Abstract excerpt

Epigenetic mechanisms contribute to the initiation and development of cancer, and epigenetic variation promotes dynamic gene expression patterns that facilitate tumor evolution and adaptation. While the NCI-60 panel represents a diverse set of human cancer cell lines that has been used to screen chemical compounds, a comprehensive epigenomic atlas of these cells has been lacking. Here, we report an integrative...

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Identifiers

PMID: 33658503
DOI: 10.1038/s41467-021-21707-1
PMCID: PMC7930052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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