Article

Complement-dependent synapse loss and microgliosis in a mouse model of multiple sclerosis

2019-07-31

Abstract excerpt

Multiple sclerosis (MS) is an inflammatory, neurodegenerative disease of the CNS characterized by both grey and white matter injury. Microglial activation and a reduction in synaptic density are key features of grey matter pathology that can be modeled with experimental autoimmune encephalomyelitis (EAE). Complement deposition combined with microglial engulfment has been shown during normal development and in dise...

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Literature Corpus work: 4c73870e-6554-59e3-96f8-908e4a4bd767
DOI: 10.1101/720649

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