Article
Dark microglia: A new phenotype predominantly associated with pathological states.
Glia - 1 May 2016
Bisht Kanchan, Sharma Kaushik P, Lecours Cynthia, Sánchez Maria Gabriela, El Hajj Hassan, Milior Giampaolo, Olmos-Alonso Adrián, Gómez-Nicola Diego, Luheshi Giamal, Vallières Luc, Branchi Igor, Maggi Laura, Limatola Cristina, Butovsky Oleg, Tremblay Marie-Ève
Abstract excerpt
The past decade has witnessed a revolution in our understanding of microglia. These immune cells were shown to actively remodel neuronal circuits, leading to propose new pathogenic mechanisms. To study microglial implication in the loss of synapses, the best pathological correlate of cognitive decline across chronic stress, aging, and diseases, we recently conducted ultrastructural analyses. Our work uncovered...
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