Article

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain

2024-12-20

Abstract excerpt

C1q, the initiating protein of the classical complement cascade, mediates synapse loss in development and disease. In various mouse models of neurologic diseases, including Alzheimer’s disease, C1q, which is secreted by microglia, the brain’s resident macrophages, is found deposited on synapses in vulnerable brain regions. However, what underlies C1q deposition on synapses in the adult brain is unclear. Using in...

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Literature Corpus work: 42d62fdb-bb60-50ff-bb9f-d9e0a8dc763d
DOI: 10.1101/2024.12.18.629085

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