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The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria

1 Feb 2022

Abstract excerpt

L9 is a potent human monoclonal antibody (mAb) that preferentially binds two adjacent NVDP minor repeats and cross-reacts with NANP major repeats of the Plasmodium falciparum circumsporozoite protein (PfCSP) on malaria-infective sporozoites. Understanding this mAb's ontogeny and mechanisms of binding PfCSP will facilitate vaccine development. Here, we isolate mAbs clonally related to L9 and show that this B cell...

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PMID: 35172158
DOI: 10.1016/j.celrep.2022.110367

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