Article

Deep learning-enabled scaffolding of spatial arrays of PfCSP epitopes

2025-07-18

Abstract excerpt

Malaria is a leading cause of disease in developing countries. The licensed malaria vaccine RTS,S/AS01 confers partial protection in part due to the elicitation of circumsporozoite protein (CSP) antibodies, of which those to the CSP repeat and junctional regions offer the most potent protection. Anti-repeat region antibodies, including the protective antibody L9, frequently develop mutations that promote inter-Fab...

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Literature Corpus work: 70c4c5c1-5611-5f76-9253-9ce82a2bdd8b
DOI: 10.1101/2025.07.16.665242

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