Article

Alpha-synuclein propagation trajectories in a population-based postmortem cohort

2026-01-18

Abstract excerpt

Parkinson’s disease and dementia with Lewy bodies are defined neuropathologically by the accumulation of α-synuclein. Postmortem studies have led to theories that pathology propagates systematically along anatomical brain networks. Yet, existing staging systems present conflicting patterns of pathology distribution. Recent work suggests that these discrepancies may reflect heterogeneous “brain-first” and “body-fir...

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Literature Corpus work: e91af52b-b75e-58b9-8a0a-d3cee01c0433
DOI: 10.64898/2026.01.13.26343943

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