Article

Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease

2025-10-22

Abstract excerpt

Dementia in Lewy body diseases (LBD) is common and arises through heterogeneous and incompletely understood pathways. Evidence suggests contributions from genetic factors, including APOE ε4 genotype, co-pathology including concomitant Alzheimer’s disease pathology and hypoperfusion related to orthostatic hypotension. However, the relative impact of these factors remains unclear. To address this, we analysed 399 po...

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Literature Corpus work: babdface-4675-5ee2-bc9a-0e672f69aa8d
DOI: 10.1101/2025.10.20.25338378

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