Article

Cerebrospinal fluid and brain α-synuclein seed amplification in autopsy-confirmed Lewy body disease relates to the distribution of pathology

2022-03-02

Abstract excerpt

<h4>Objective</h4> To determine the sensitivity and specificity of α-synuclein seed amplification assay (αSyn-SAA) in antemortem and postmortem CSF and brain homogenate samples of autopsy-confirmed patients with a spectrum of Lewy-related pathology (LRP). <h4>Methods</h4> Antemortem CSF samples were examined from 119 subjects with standardized neuropathological examinations from OHSU and UCSD (56 additional post...

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Literature Corpus work: f42a7349-28c0-58e4-a1ed-de16c70f53b7
DOI: 10.1101/2022.02.28.22271232

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