Article

In vivo and in silico alpha-synuclein propagation dynamics: The role of genotype, epicentre, and connectivity

2025-07-22

Abstract excerpt

Neurodegeneration observed in synucleinopathies, like Parkinson’s disease (PD), are hypothesized to be a consequence of the progressive accumulation and spread of misfolded alpha-synuclein (aSyn) throughout the brain. Here, we study the generalizability of this hypothesis across multiple biologically-relevant factors including genotype, aSyn species, and regional vulnerability (i.e.: does the introduction of aSyn...

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Literature Corpus work: 1248cb2c-12c1-5b3e-8acb-cc3a9253bab8
DOI: 10.1101/2025.07.18.665565

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