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Article

Four distinct trajectories of tau deposition identified in Alzheimer's disease.

Nature medicine - 1 May 2021

Vogel Jacob W, Young Alexandra L, Oxtoby Neil P, Smith Ruben, Ossenkoppele Rik, Strandberg Olof T, La Joie Renaud, Aksman Leon M, Grothe Michel J, Iturria-Medina Yasser, Pontecorvo Michael J, Devous Michael D, Rabinovici Gil D, Alexander Daniel C, Lyoo Chul Hyoung, Evans Alan C, Hansson Oskar

Abstract excerpt

Alzheimer's disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33927414
DOI: 10.1038/s41591-021-01309-6
PMCID: PMC8686688

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