Article

Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold

2020-11-18

Abstract excerpt

Centriole biogenesis and maintenance are crucial for cells to generate cilia and assemble centrosomes that function as microtubule organizing centers (MTOCs). Centriole biogenesis and MTOC function both require the microtubule nucleator γ-tubulin ring complex (γTuRC). The widely accepted view is that γTuRC localizes to the pericentriolar material (PCM), where it nucleates microtubules. γTuRC has also been observed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de107b34-10d7-5e91-9698-4ddae343f389
DOI: 10.1101/2020.11.18.384156

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffoldDOI 10.1101/2020.11.18.384156Read

CCDC15 localizes to the centriole inner scaffold and regulates centriole integrity and ciliogenesisSemantic proximity Read

The connecting cilium inner scaffold provides a structural foundation to maintain photoreceptor integritySemantic proximity Read

NDE1 Localizes to the Subdistal Appendages to Maintain Centrosome Integrity and Microtubule OrganizationSemantic proximity Read

The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and AppendagesSemantic proximity Read

Recent advances in pericentriolar material organization: ordered layers and scaffolding gelsSemantic proximity Read

Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control.Semantic proximity Read

Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.Semantic proximity Read

Evolutionary conservation of centriole rotational asymmetry in the human centrosomeSemantic proximity Read

Drosophila PLP assembles pericentriolar clouds that promote centriole stability, cohesion and MT nucleation.Semantic proximity Read

Separation-of-function MCPH-associated mutations in CPAP affect centriole number and length.Semantic proximity Read

Neuro-ophthalmic disorders resulting from defects in the gamma tubulin ring complex: a clinically oriented review.Semantic proximity Read

A ciliopathy complex builds distal appendages to initiate ciliogenesisSemantic proximity Read