Article

Dual roles of IQCG, a novel microtubule nucleation factor rapidly evolving in humans

2024-12-17

Abstract excerpt

The centrosome serves as the main microtubule-organizing structure, playing crucial roles in animal development. Uncovering new components and elucidating their functions helps to understand the regulation of cell maintenance and division by the centrosome. In this study, through a combination of genetic analyses and cell biological characterizations, we identify IQ Motif Containing G (IQCG) as a novel microtubule...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6036f99-2a30-54e3-b0a2-683a6637c301
DOI: 10.1101/2024.12.16.628806

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dual roles of IQCG, a novel microtubule nucleation factor rapidly evolving in humansDOI 10.1101/2024.12.16.628806Read

Emerging roles of centrosome cohesionSemantic proximity Read

The Tubulin Code in Mitosis and CancerSemantic proximity Read

Auto-inhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defectsSemantic proximity Read

Human genetic variations reveal Chromosomal Instability aiding Variants (CIVa) in kinetochore-microtubule associated proteinsSemantic proximity Read

The centrosome cycleSemantic proximity Read

MZT1 regulates microtubule nucleation by linking γTuRC assembly to adapter-mediated targeting and activation.Semantic proximity Read

In vitro reconstitution of minimal human centrosomesSemantic proximity Read

Functional dissection of human mitotic genes using CRISPR-Cas9 tiling screensSemantic proximity Read

Less is More: Nek2A Unclusters Extra Centrosomes and Induces Cell Death in Cancer Cells via KIF2C InteractionSemantic proximity Read

STNM1 in human cancers: role, function and potential therapy sensitizerSemantic proximity Read

IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome StabilitySemantic proximity Read

Origins and consequences of centrosome aberrations in human cancersSemantic proximity Read