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Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification

2 Mar 2023

Abstract excerpt

Centrosome amplification (CA) is a hallmark of cancer that is strongly associated with highly aggressive disease and worse clinical outcome. Clustering extra centrosomes is a major coping mechanism required for faithful mitosis of cancer cells with CA that would otherwise undergo mitotic catastrophe and cell death. However, its underlying molecular mechanisms have not been fully described. Furthermore, little is...

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PMID: 36864125
DOI: 10.1038/s41418-023-01140-1

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