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Article

MZT1 regulates microtubule nucleation by linking γTuRC assembly to adapter-mediated targeting and activation.

Journal of cell science - 15 Jan 2017

Cota Rosa Ramírez, Teixidó-Travesa Neus, Ezquerra Artur, Eibes Susana, Lacasa Cristina, Roig Joan, Lüders Jens

Abstract excerpt

Regulation of the γ-tubulin ring complex (γTuRC) through targeting and activation restricts nucleation of microtubules to microtubule-organizing centers (MTOCs), aiding in the assembly of ordered microtubule arrays. However, the mechanistic basis of this important regulation remains poorly understood. Here, we show that, in human cells, γTuRC integrity, determined by the presence of γ-tubulin complex proteins...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27852835
DOI: 10.1242/jcs.195321

Genes

MZT1
NEDD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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