Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.

Nature cell biology - 1 Feb 2006

Lüders Jens, Patel Urvashi K, Stearns Tim

Abstract excerpt

The gamma-tubulin ring complex (gammaTuRC) is a large multi-protein complex that is required for microtubule nucleation from the centrosome. Here, we show that the GCP-WD protein (originally named NEDD1) is the orthologue of the Drosophila Dgrip71WD protein, and is a subunit of the human gammaTuRC. GCP-WD has the properties of an attachment factor for the gammaTuRC: depletion or inhibition of GCP-WD results in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens
Share to Centrosome
Share to Microtubule-Associated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubules

Share to Mitosis

Share to Nocodazole

Share to Spindle Apparatus

Share to Tubulin

Source

Identifiers

PMID: 16378099
DOI: 10.1038/ncb1349

Genes

NEDD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.PMID 16378099Read ↗

MZT1 regulates microtubule nucleation by linking γTuRC assembly to adapter-mediated targeting and activation.Semantic proximity Read ↗

A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome.Semantic proximity Read ↗

Drosophila melanogaster gamma-TuRC is dispensable for targeting gamma-tubulin to the centrosome and microtubule nucleation.Semantic proximity Read ↗

Auto-inhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defectsSemantic proximity Read ↗

The gammaTuRC components Grip75 and Grip128 have an essential microtubule-anchoring function in the Drosophila germline.Semantic proximity Read ↗

Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization.Semantic proximity Read ↗

Drosophila Xpd regulates Cdk7 localization, mitotic kinase activity, spindle dynamics, and chromosome segregation.Semantic proximity Read ↗

The DNA replication protein Cdc6 inhibits the microtubule-organizing activity of the centrosome.Semantic proximity Read ↗

Wdr62 and Patronin cooperate to organize distinct acentrosomal microtubule networks during <i>Drosophila</i> oogenesisSemantic proximity Read ↗

A new Augmin subunit, Msd1, demonstrates the importance of mitotic spindle-templated microtubule nucleation in the absence of functioning centrosomes.Semantic proximity Read ↗

Analysis of Tub4p, a yeast gamma-tubulin-like protein: implications for microtubule-organizing center function.Semantic proximity Read ↗

GCP6 is a substrate of Plk4 and required for centriole duplicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.