Article
DNA mismatch repair preferentially protects genes from mutation.
Genome research - 1 Jan 2018
Belfield Eric J, Ding Zhong Jie, Jamieson Fiona J C, Visscher Anne M, Zheng Shao Jian, Mithani Aziz, Harberd Nicholas P
Abstract excerpt
Mutation is the source of genetic variation and fuels biological evolution. Many mutations first arise as DNA replication errors. These errors subsequently evade correction by cellular DNA repair, for example, by the well-known DNA mismatch repair (MMR) mechanism. Here, we determine the genome-wide effects of MMR on mutation. We first identify almost 9000 mutations accumulated over five generations in eight...
Topics
- Arabidopsis
- DNA Mismatch Repair
- Evolution, Molecular
- Genome, Plant
- Mutagenesis
- Mutation