Article

Disentangling sources of clock-like mutations in germline and soma

2023-09-12

Abstract excerpt

The rates of mutations vary across cell types. To identify causes of this variation, mutations are often decomposed into a combination of the single base substitution (SBS) “signatures” observed in germline, soma and tumors, with the idea that each signature corresponds to one or a small number of underlying mutagenic processes. Two such signatures turn out to be ubiquitous across cell types: SBS signature 1, whic...

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Literature Corpus work: ee5a84a9-bcea-59e7-9819-d43dde5d2182
DOI: 10.1101/2023.09.07.556720

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