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Article

Characterisation of the spectrum and genetic dependence of collateral mutations induced by translesion DNA synthesis.

PLoS genetics - 1 Feb 2022

Póti Ádám, Szikriszt Bernadett, Gervai Judit Zsuzsanna, Chen Dan, Szüts Dávid

Abstract excerpt

Translesion DNA synthesis (TLS) is a fundamental damage bypass pathway that utilises specialised polymerases with relaxed template specificity to achieve replication through damaged DNA. Misinsertions by low fidelity TLS polymerases may introduce additional mutations on undamaged DNA near the original lesion site, which we termed collateral mutations. In this study, we used whole genome sequencing datasets of...

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Identifiers

PMID: 35130276
DOI: 10.1371/journal.pgen.1010051
PMCID: PMC8870599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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